Integrated vial filling machine for aseptic and toxic processing of pharmaceuticals

The integra is a state-of-the-art vial filling machine designed to minimize product loss at every stage of production. From the moment it is started up, the groninger solution ensures that the first vial per filling head is already filled with the exact volume required. This ensures that there is no wastage of precious product during the initial stages of production.

As production continues, the pumps can be controlled individually to ensure that only the last filled vial per filling head could show an underfill. This means that even if there is a malfunction in the system or an issue with the pump, the product loss is kept to an absolute minimum.

To further reduce the risk of product rejects and minimize waste, the integra can be designed with a stopper repositioning function. This allows for any loss of a stopper to be compensated by repositioning it in the system. With this function, the integra ensures that every single product is of the highest possible quality, while minimizing any unnecessary waste.

Our stopper transport bowl is not only innovative, but also highly efficient. The integrated sorting device allows for easy cleaning, making it a breeze to maintain aseptic conditions. Furthermore, the reduced number of stopper-dependent format parts means changeovers can be performed quickly and efficiently, saving valuable time and resources.

But that's not all. The sorting and feeding unit is designed with optimal visibility in mind, ensuring that operators can easily monitor the process and make adjustments as necessary. And with the walking beam's ability to be adjusted using a servo motor, the machine can be configured for various processing objects, resulting in a 50% reduction in format part changes compared to traditional production lines.

The stopper transport bowl of the integra is truly versatile and adaptable, providing a streamlined and efficient solution for your production needs.

The Integra's low machine depth makes it possible to extract air from one side in the filling and discharge area, with filter cartridges attached to the back of the isolator. Additionally, the entire line is equipped without vacuum for processing toxic products. The mechanical stopper setting function, mechanical rejects ejection, and avoidance of bellows seals ensure the optimal processing of toxic products while keeping the necessary cleaning requirements in mind.

The slim machine design of the entire system is an essential element of the integra. The low depth of intervention makes it possible to operate the entire system from one side, during setup and during operation.

The low machine depth of 650 mm also makes it possible for all line areas to be easily reached during cleaning. The line can also be set up at an angle allowing the cleaning medium to drain directly into a drain located on the back of the isolator directly in front of the HEPA filter cartridges.

The integra filling machine is a game-changer in the pharmaceutical industry, as it seamlessly integrates the sterile barrier into the filling process. This innovative technology not only streamlines the filling process, but also ensures the highest level of sterility for the final product. To achieve this level of cleanliness, the integra employs SKANFOG decontamination technology, which has been proven to effectively eliminate any potential contaminants.

What sets the integra apart from other filling machines is its compact design, which allows for the shortest cycle times possible. This means that the entire filling process, from decontamination to filling, can be completed in a fraction of the time it would take with traditional filling methods. By reducing the time needed for the filling process, pharmaceutical manufacturers can produce more products in less time, ultimately increasing their productivity and profitability.

integra's innovative design ensures that the HEPA filters are securely installed in filter cartridges called FIPAs. These cartridges can be conveniently unlocked either manually or with the fully automated panel control. This feature is especially critical when dealing with toxic materials because the design guarantees that there is no risk of contamination to the environment or operators. Hence, integra provides a safe and reliable solution for hazardous processing, ensuring a healthy and hazard-free environment for everyone.