integra: Completely integrated isolator bulk vial filling line. 100% reliability and safety from the start.
The processing of aseptic and toxic products in the pharmaceutical and biotech industry places special demands on islated filling line construction design. With the integra vial filling machine developed jointly by groninger + SKAN, we have introduced an integrated machine concept with harmonized filling and isolator technology. From the conceptual phase through design and manufacturing, the whole process has been standardized. These core elements bring certainty and safety to every step of your filling line project.
Highlights of the integra
- Systematically secured interfaces between the groninger + SKAN lines for established market standard
- Merging separate functional units into a sophisticated and holistic line concept
- Pre-sourced components in stock and reserved for your integra
- Allocated resources, throughout the entire life cycle of your project
More information on our integra
Washing
Unpacking, feeding, washing and drying of vials.
Depyrogenation
Sterilization and depyrogenization with 3-log or 6-log.
Filling & closing
Filling and closing of all standard utilizing vials.
Freeze-drying
Integrating freeze-drying equipment from all known suppliers.
Capping
Particle-reduced capping of vials with groninger patented singledisc technology.
- Reduced contamination risk: The ultra slim machine design enables an one-sided operation and cleaning of the entire line, minimizing the amount of glove ports
- Shortest changeover times: groninger quickconnect enables the fastest, toolless changeover of the complete line
- Highest machine efficiency: Minimal product loss during run-in and run-empty modes eliminates waste and consequently increases profit with our smartfill technology
- Ideal for toxic processing: Vacuum-free stoppering and reject station is the basis for processing highly potent/toxic products
- Optimized filter handling: Return air channels are protected with HEPA filter cartridges (FiPa) to enable safe filter changes and aseptic-toxic processing. The cartridges can be locked automatically - no more need for complex bag-in/bag-out procedures
- 100% In-Process-Control (IPC)
- Minimum residual oxygen content of =1%
- All common standard filling systems and gassing functions
- Re-closing function
- Vacuum-free line for toxic products
- Minimum product loss in infeed and idle mode thanks to groninger smartfill technology
- All common barrier systems
- Highest operator and product protection in aseptic toxic processing
- Innovative ergonomic design and easy access allow cleaning and operation from one side
- Reliable airflow between two barrier-forming HEPA filters
- Fastest cycles with the latest SKANFOG® decontamination technology (H2O2 cycle time 1 hour < 1 ppm)
- Integrated NANOX® catalyst technology from SKAN (one-pass degradation of H2O2; 0.1 ppm)
- Validable and repeatable cleaning procedure
- Automated, safe HEPA filter system (“FIPA”) change
Partner
Partners for health. Solutions for life.
groninger + SKAN
For over 30 years, the best engineers from both companies have been collaborating on the same vision
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